You cannot start with an “empty” sheet in Airtable. You must define each column/field as you create it. You must create each row. In a well designed Airtable base, there are no completely empty columns or rows.
Airtable cannot do calculations down columns the way a spreadsheet can. You can see a limited number of calculations down columns using the summary bar, but those values cannot be used as inputs to other calculations.
Airtable can do calculations across rows using formula fields. Note that the calculations can only take inputs from the same row, they cannot reference the row above or below.
There are workarounds to more complex calculations using linked tables and rollup fields, but if you are new to Airtable and databases, that might be a bit much to take in at first.
Best of luck in learning about Airtable!