This is possible, but only if you know for a fact that you will only have two values in each set.
Try this:
VALUE(LEFT({Field 1}, FIND(",", {Field 1}) - 1)) * VALUE(LEFT({Field 2}, FIND(",", {Field 2}) - 1)) & "," & VALUE(RIGHT({Field 1}, FIND(",", {Field 1}) + 1)) * VALUE(RIGHT({Field 2}, FIND(",", {Field 2}) + 1))
