Welcome to the Airtable Community!
try this formula:
SUBSTITUTE(IF(ISBN13!="", CONCATENATE(ISBN13, "5", {US PRICE})), ".", "")
Some more information on the Substitute Function:
SUBSTITUTE(string, old_text, new_text, [index])
This function works by first passing a string (which you created by concatenating your values together), and then as your second parameter you pass the value you would like to replace ".", in the case the period needs to be encapsulated by "" so that Airtable recognizes this value to be a string. Since you want to remove the period, you can think of it as replacing the period with nothing. You accomplish this by passing quotation marks with nothing in it "" as your third parameter. The forth parameter is optional and allows you to specify which instance of your "old_text" to replace, for example if your string had 2 periods and you put 2 in the 4th position you would only be removing the second period in your string.
Hope this helps!